Ulcera de Buruli (large painless ulcer) caused by Mycobacterium ulcerans, seen in the leg of a Kenyan adult (HE). Diffuse coagulative necrosis is formed in the dermis though subcutaneous tissue. Undermining ulceration is characteristic. No granulomatous reaction is seen

Radiograph Showing Destructive Lesions Suggestive of Chronic Osteomyelitis.